ME
Having a friend or family member with fibromyalgia or chronic
fatigue syndrome is difficult. You may be facing extra burdens or a
strained relationship, or even doubts that the person you care about
is really sick. These are all normal issues, and the resources here
can help you handle them. To read more:
From Co-Cure "Enteroviral myalgic
encephalomyelitis - EvME" by Dr. Irving Spurr
A treatise on EvME by Dr. Irving Spurr who argues that "The enteroviruses, ubiquitous in nature, are responsible for a variety of human diseases ranging from mild gastroenteritis to fulminating multi-organ failure. They are the cause of myalgic encephalomyelitis, and it is no surprise that this disease has multi-organ involvement with protean manifestation."
http://www.meresearch.org.uk/information/keypubs/EvME.pdf
A treatise on EvME by Dr. Irving Spurr who argues that "The enteroviruses, ubiquitous in nature, are responsible for a variety of human diseases ranging from mild gastroenteritis to fulminating multi-organ failure. They are the cause of myalgic encephalomyelitis, and it is no surprise that this disease has multi-organ involvement with protean manifestation."
http://www.meresearch.org.uk/information/keypubs/EvME.pdf
Postural orthostatic tachycardia syndrome
is an under-recognized
condition in chronic fatigue syndrome.
condition in chronic fatigue syndrome.
The Immunological Aspects of CFS (From
Autoimmunity Reviews, Italy)
"Similar disorders (as CFS) have been described for at least two
centuries and have been differently named neurasthenia, post-viral
fatigue, myalgic encephalomyelitis and chronic mononucleosis.
Recent longitudinal studies suggest that some people affected by
CFS improve with time but that most remain functionally impaired
for several years. The estimated worldwide prevalence of CFS if
0.4-1% and it affects over 800,000 people in the US and
approximately 240,00 patients in the UK. No physical examination
signs are specific to CFS and no diagnostic tests identify this
syndrome. The pathophysiological mechanism of CFS is unclear.
The main hypothesis include altered central nervous system
functioning resulting from an abnormal immune response against a
common antigen; a neuroendocrine disturbance; cognitive impairment
caused by response to infection or other stimuli in sentient
people The current concept is that CFS pathogensis is is aa
multifactorial condition. Various studies have sought evidence
for a disturbance in immunity in people with CFS. An alteration in
Cytokine profile, a decreased function of natural killer (NK)
cells , a presence of autoantibodies and reduced responses of T
cells to mitogens and other specific antigens have been reported,
The observed high level of pro-inflammatory cytokines may explain
some of the manifestations such as fatigue and flu-like symptoms
and influence NK activity." To read more:
From CoCure:
EVIDENCE OF STAPHYLOCOCCUS BIOFILM IN CHRONIC FATIGUE
SYNDROME
S. E. Fry; Airpark Medical Center, Scottsdale, AZ.
Chronic Fatigue Syndrome (CFS) is characterized by unrelenting fatigue of greater than 6 months duration without evidence of other known disease. Its origin has been hypothesized to be either psychiatric or viral. Recent work has implicated coagulase negative staphylococcus as the etiologic agent. Culture studies to date have been inconclusive. One approach to confirm this hypothesis is to search for biofilm constituents. Lipoteichoic acid (Teichoic acid) is considered a constituent of Staphylococcus biofilm and the detection of antibodies to it have been in clinical use for nearly 20 years. The level of antibody has been used as an indicator of Staphylococcus infection and especially helpful in detecting Staphylococcus in endocarditis and osteomyelitis. The presence of Teichoic acid antibody in the normal population has been reported to be between 1-5%.
S. E. Fry; Airpark Medical Center, Scottsdale, AZ.
Chronic Fatigue Syndrome (CFS) is characterized by unrelenting fatigue of greater than 6 months duration without evidence of other known disease. Its origin has been hypothesized to be either psychiatric or viral. Recent work has implicated coagulase negative staphylococcus as the etiologic agent. Culture studies to date have been inconclusive. One approach to confirm this hypothesis is to search for biofilm constituents. Lipoteichoic acid (Teichoic acid) is considered a constituent of Staphylococcus biofilm and the detection of antibodies to it have been in clinical use for nearly 20 years. The level of antibody has been used as an indicator of Staphylococcus infection and especially helpful in detecting Staphylococcus in endocarditis and osteomyelitis. The presence of Teichoic acid antibody in the normal population has been reported to be between 1-5%.
Twelve patients meeting the CDC criteria for CFS and Fibromyalgia
were tested for antibodies to Teichoic acid. Two national
reference laboratories both utilizing a radio-immunodiffusion
assay were utilized. Two of the patients were male, the remaining
ten patients were female, ages were between 18 and 61 years of
age. A titer of 1:2 or greater was found in eight patients, of
these, two were at a titer of 1:4 and two were at a titer of 1:8.
This small sample displays evidence of elevated antibody to
Teichoic acid in 66% of patients tested, far above the expected
level in the normal population. This information further suggests
that a Staphylococcal organism, with biofilm may be the causal
agent in CFS and Fibromyalgia.
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